![]() Advances in the care of patients with mucinous colorectal cancer. Hugen N, Brown G, Glynne-Jones R, de Wilt JH, Nagtegaal ID. ![]() Gastrointestinal cancers in China, the USA, and Europe. Weitz J, Koch M, Debus J, Höhler T, Galle PR, Büchler MW. ![]() A high carcinoembryonic antigen level (p = 0.034, hazard ratio: 1.86), rectal cancer (p = 0.035, hazard ratio: 1.81), LVI (p = 0.002, hazard ratio: 3.59) and dMMR phenotypes (p = 0.009, hazard ratio: 2.85) were independently related to short disease-free survival of stage I CRC.Ĭompared with non-MAC, MAC patients had more T2 patients and more dMMR phenotypes in stage I CRC at presentation, but the mucinous histology is not a significant predictor of recurrence and prognosis in stage I CRC.Ĭolorectal cancer Colorectal carcinoma Mucinous adenocarcinoma Overall survival Recurrence-free survival. On multivariate analysis, older age (p = 0.009, hazard ratio: 2.22), rectal cancer (p = 0.008, hazard ratio: 3.21), lymphovascular invasion (LVI) (p < 0.001, hazard ratio: 6.28), and deficient mismatch repair (dMMR) phenotypes (p = 0.044, hazard ratio: 2.62) were independently associated to poor survival of stage I CRC. There was no difference in disease-free survival and overall survival between MACs and non-MACs. The rate of recurrence was 15.3% and the mortality was 9.2% among all stage I CRC patients. MACs were observed more frequently located in the colon than rectum (p = 0.049), more frequently displayed the deficient mismatch repair (dMMR) phenotype (p = 0.001) and had a greater frequency of T2 stage (p = 0.002). Multivariate analysis was performed to determine whether mucinous histotype itself was an independent prognostic impact in stage I patients. ![]() This study determined the clinicopathologic characteristics and long-term outcome of stage I colorectal mucinous adenocarcinomas (MAC).Īmong the total of 530 patients with stage I CRC (58 having MAC and 472 having non-MAC) who underwent radical resection, the correlation between clinicopathological factors and MAC was analyzed. The prognostic value of the mucinous adenocarcinoma histotype on the early stages especially for stage I colorectal cancer (CRC) is still unclear. ![]()
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